Arsenic Trioxide, a Novel Mitochondriotoxic Anticancer Agent?
نویسندگان
چکیده
منابع مشابه
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At an acute ingestion of arsenic trioxide, nausea, vomiting, diarrhea, and abdominal pain are early symptoms occurring within 30 min to several hours. Primary target organ is the gastrointestinal tract (GIТ), where hemorrhagic gastroenteritis can occur in serious cases. Among cardiovascular symptoms are tachycardia, ventricular fibrillation, and heart failure described. Neurological symptoms ca...
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Arsenic compounds have been used for medicinal purposes throughout history. Arsenic trioxide (As2O3) achieved dramatic remissions in patients with acute promyelocytic leukaemia. Unfortunately, the clinical usefulness of As2O3 has been limited by its toxicity. The present study was designed to investigate the toxic effects of As2O3 at its clinical concentrations. Experimental rats were administe...
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ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 1999
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/91.9.743